91精品乱码久久蜜桃麻豆,www.17c.com国产大片,寡妇高潮一级毛片免费看,久久人妻少妇嫩草av
B3-pcbanner.jpg B3-phbanner.jpg
News
Ribo Presents First-In-Class FXI Targeting siRNA Drug RBD4059 Phase Ⅰ Clinical Data At ESC Congress 2024
Aug 31,2024

Aug. 31, 2024 - Gothenburg - Kunshan - Beijing


Suzhou Ribo Life Science Co., Ltd. (Ribo) announced that the first clinical data from its completed Phase I study of the world′s first and most advanced hemostasis-sparing antithrombotic Factor XI (FXI) targeting siRNA asset, RBD4059, have been presented at ESC (European Society of Cardiology) Congress 2024 in London on August 31, 2024.

As reported, RBD4059 demonstrated dose dependent, predictable PK, and pronounced (>90%) and durable FXI activity and protein reduction in the dose range of 50 mg - 600 mg. Primary endpoint for safety and tolerability has been met - RBD4059 demonstrated favorable safety profile with no identified adverse safety signals across the investigated dose-range.

This first-in human study supports the further development of RBD4059 as an anticoagulant that can maintain a high level of PD effect with every 3- or 6-months dosing regimen, with potential for enhanced compliance and low bleeding risk in chronic anti-coagulant therapy.


微信圖片_20240831175159.png

Anticoagulants are essential for the prevention and treatment of thrombosis, addressing a wide range of indications including coronary artery disease, peripheral artery disease, end-stage renal disease (ESRD), atrial fibrillation (AF), venous thromboembolism (VTE), postoperative orthopedic surgery etc.  Current anticoagulants often suffer from short duration of action and high dosing frequency, coupled with bleeding risks, highlighting the urgent need for potent, long-acting anticoagulants with lower bleeding risks.

RBD4059, discovered and developed by Ribo based on its proprietary RIBO-GalSTARTM technology platform, is an innovative GalNAc-conjugated siRNA drug, which achieves anticoagulant / antithrombotic effects by inhibiting FXI and blocking the activation of the intrinsic coagulation pathway. Compared to existing antithrombotic therapies, RBD4059 offers the advantages of stronger efficacy, longer duration of action and lower bleeding risk as an siRNA drug.

Previously, RBD4059 received approval from the European Medicines Agency (EMA) for a randomized, double-blind, placebo-controlled Phase IIa clinical trial, aimed at evaluating the safety, pharmacokinetics, and pharmacodynamics of repeated subcutaneous injections of the drug in patients with stable coronary artery disease. The first patient was enrolled in August 2024.


Dr. Li Ming Gan, Co-CEO and Global Head of R&D at Ribo, remarked: "We are excited to have progressed world’s first and most advanced FXI siRNA program, now into PhaseⅡ, based on these encouraging data from Phase Ⅰ. The molecule fulfills the target product profile we set up to achieve in terms of clinically meaningful and relevant potency and duration, which clearly differentiates from all established anti-thrombotic therapies as well as profiles of all other FXI inhibition programs in clinical development, including small molecules and antibodies. Also, we are extremely encouraged to see the low inter-individual variability in treatment response, which further strengthens the first- and best-in-class potential of the program. We look forward to continuing the further clinical development of RBD4059 based on the encouraging Phase Ⅰ results, and it's believed it will bring a transformative change to the current anti-thrombotic therapy."

特级做a爰片毛片A片色戒 | 丰满熟女人妻大乳邻居 | 久久毛片www.17c.com | www.17c.com喷水少妇 | 中国丰满熟女A片免费观 | 67194熟妇在线观看 | 日本在线视频免费观看 | 麻豆精品秘 国产传媒AV | 欧美一级婬片A片免费软件 国产性猛交 XX 乱照片 | 新sss在线观看丝 | 四虎无码在线精品一区二区 | 强伦人妻一区二区三区视频18 | 91丨牛牛丨国产人妻 | 农村51妇女亂伦91 | 全免费A级毛片免费看网站招嫖 | 91人妻久久久精品中文字幕瑜伽 | 免费婬片A片无码人妻 | 免费直接在线看黄网站 | 91国语对白爽死我了第30集 | 亚洲精品粉嫩小泬18p | 国产精品午夜未成人免费观看 | 91在线无码精品秘 传媒 | 美女裸体免费视频久久久 | 囯产精品久久久久久久久在饯观看 | 国产人妻 9 9精品无码一区李宗瑞 | 亚洲一本在线电影av | 海角社真实XXⅩ人伦 | 麻豆极品JK丝袜自慰喷水久久 | 91精品久久久久久久久久浪潮 | 风韵丰满熟妇啪啪区老熟熟女 | 五月激情丁香婷婷综合第九激情 | 少妇搡BBBB搡BBB搡毛片 | 黄色电影免费在线观看 | 农村妇女一级A片免费播放 无码中文AV一区二区三巨 | 国产一区二区三区操逼不卡视频 | 免费无码婬片AAAA片直播黑人 | 国产护士囗交吞精视频 | 亚洲一区二区三区入口 | 少妇熟女视频一区二区三区 | 鲁大师手机在线日韩 | 18禁成人老师免费看入口 |